Lentiviral mediated expression of soluble Neuropilin 1 inhibits Semaphorin 3A-mediated Collapse Activity in vitro
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چکیده
منابع مشابه
Expression of Semaphorin 3A and Neuropilin 1 in Asthma
Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis of asthma. Therefore, it is possible that SEMA3A plays a role in the pathogenesis of asthma through attenuation of VEGF-mediated effects. In the present study, we aimed to evaluate express...
متن کاملControl of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions.
It is largely established that molecules first discovered in the nervous system are also found in the immune system. Neuropilin-1 (NP-1) was initially identified to mediate semaphorin-induced chemorepulsion during brain development and is also involved in peripheral T cell/dendritic cell interactions. Herein, we studied NP-1 during T cell development in the human thymus. NP-1 is expressed in bo...
متن کاملPlexin-Neuropilin-1 Complexes Form Functional Semaphorin-3A Receptors
Class 1 and 3 semaphorins repulse axons but bind to different cell surface proteins. We find that the two known semaphorin-binding proteins, plexin 1 (Plex 1) and neuropilin-1 (NP-1), form a stable complex. Plex 1 alone does not bind semaphorin-3A (Sema3A), but the NP-1/Plex 1 complex has a higher affinity for Sema3A than does NP-1 alone. While Sema3A binding to NP-1 does not alter nonneuronal ...
متن کاملExpression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer
OBJECTIVE To investigate the association between semaphorin 3A (SEMA 3A) and its receptor neuropilin 1 (NRP1) and the clinicopathologic characteristics of patients with tongue cancer. STUDY DESIGN Forty-three tongue squamous cell carcinoma specimens were included. Immunohistochemical staining of SEMA3A and NRP1 was performed on 15 normal tongue epithelium specimens and the 43 tumour specimens...
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ژورنال
عنوان ژورنال: Basic and Clinical Neuroscience Journal
سال: 2019
ISSN: 2228-7442,2008-126X
DOI: 10.32598/bcn.9.10.495